• TITAN PRODUCT CANDIDATES
• Probuphine^®
• Other Clinical Development Opportunities
• PARTNERED PRODUCT
  CANDIDATES

Other Clinical Development Opportunities

Other ProNeura™ Applications

ProNeura is Titan’s sustained drug delivery technology utilized in Probuphine^®, with additional potential applications where conventional treatment is limited by variability in blood drug levels and poor patient compliance. ProNeura is a continuous drug delivery system that consists of a small, solid rod made from a mixture of ethylene-vinyl acetate (EVA) and a drug substance. The resulting product is a solid matrix that is placed subcutaneously, normally in the upper arm in a simple in-office procedure, and is removed in a similar manner at the end of the treatment period, for at least six months. The drug substance is released slowly, at continuous levels, through the process of diffusion. This results in non-fluctuating and stable blood levels, similar to intravenous administration. Titan retains an exclusive worldwide license to certain U.S. and foreign patents relating to this long-term drug delivery system, and has conducted non-clinical experiments with potential treatments for Parkinson's Disease and other CNS disorders.